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Src (gen)

С Википедије, слободне енциклопедије
V-src sarkoma viralni onkogeni homolog (avijarni)
PDB prikaz baziran na 1a07​.
Dostupne strukture
1a07​, 1a08​, 1a09​, 1a1a​, 1a1b​, 1a1c​, 1a1e​, 1bkl​, 1bkm​, 1f1w​, 1f2f​, 1fmk​, 1hcs​, 1hct​, 1is0​, 1kc2​, 1ksw​, 1nlo​, 1nlp​, 1nzl​, 1nzv​, 1o41​, 1o42​, 1o43​, 1o44​, 1o45​, 1o46​, 1o47​, 1o48​, 1o49​, 1o4a​, 1o4b​, 1o4c​, 1o4d​, 1o4e​, 1o4f​, 1o4g​, 1o4h​, 1o4i​, 1o4j​, 1o4k​, 1o4l​, 1o4m​, 1o4n​, 1o4o​, 1o4p​, 1o4q​, 1o4r​, 1p13​, 1prl​, 1prm​, 1qwe​, 1qwf​, 1rlp​, 1rlq​, 1sha​, 1shb​, 1shd​, 1skj​, 1spr​, 1sps​, 1srl​, 1srm​, 1y57​, 1yi6​, 1yoj​, 1yol​, 1yom​, 2bdf​, 2bdj​, 2h8h​, 2hwo​, 2hwp​, 2oiq​, 2ptk​, 2src​
Identifikatori
Simboli SRC; ASV; SRC1; c-SRC; p60-Src
Vanjski ID OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6714 20779
Ensembl ENSG00000197122 ENSMUSG00000027646
UniProt P12931 Q2M4I4
RefSeq (mRNA) NM_005417 NM_001025395
RefSeq (protein) NP_005408 NP_001020566
Lokacija (UCSC) Chr 20:
35.41 - 35.47 Mb		 Chr 2:
157.12 - 157.16 Mb
PubMed pretraga [1] [2]

Src je proto-onkogenska tirozinska kinaza. Src su otkrili Mihael Bišop i Harold Varmus. Za ovo otkriće im je dodeljena Nobelova nagrada za fiziologiju ili medicinu 1989. godine.[1] Ova kinaza pripada familiji nespecifičnih proteinskih tirozinskih kinaza koja se naziva Src familijom kinaza. Otkriće Src porodice proteina je imalo presudnu ulogu u modernom shvatanju rak kao bolesti u kojoj se inače zdrava ćelijska signalizacija pokvari.

Ovaj gen je sličan sa v-src genom Rous sarkoma virusa. Ovaj proto-onkogen može da igra ulogu u regulisanju embrionalnog razvoja i rasta ćelija. Proteinska kinaza koju ovaj gen kodira se može inhibirati fosforilacijom c-SRC kinazom. Mutacije ovog gena mogu da učestvuju u malignom razvoju raka debelog creva. Dve transkriptne varijante koje kodiraju isti protein su nađene za ovaj gen.[2]

Interactions

[уреди | уреди извор]

Za Src gen je bilo pokazano da interaguje sa GRIN2A,[3][4] C-Raf,[5] CD44,[6] Jedreni translokator arilnog ugljovodoničnog receptora,[7] Aryl hydrocarbon receptor,[7] PDE6G,[8] STAT1,[9][10] EPH receptor B2,[11][12] Androgenski receptor,[13][14][15] Proteinska kinaza Mζ,[16] STAT3,[17] Grb2,[8][18] Beta-3 adrenergički receptor,[19] Kinaza beta adrenergičkog receptora,[8] Receptor epidermalnog faktora rasta,[9][20][21] PTK2,[22][23][24][25][26][27] DAB2,[28] EPS8,[29] Distroglikan,[30] Estrogenski receptor alfa,[13][31][32][33] Estrogenski receptor beta,[13][33] HNF1A,[34] KHDRBS1,[35][36][37][38][39] DDEF1,[40] MUC1,[41][42] PTK2B,[20][43][44] BCAR1,[45][22][46][47][48][24] SHB,[49] PLD2,[50] Faktor responsa seruma,[51] NCOA6,[52][53][54][55] Receptor retinoiske kiseline alfa,[32][56] Protein Viskot-Oldrić sindroma,[57][58] RICS,[59] RAS p21 proteinski activator 1,[60][61] MT-ND2[62] i GNB2L1.[63]

Reference

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  1. ^ Nobel Prize in Physiology or Medicine for 1989 jointly to J. Michael Bishop and Harold E. Varmus for their discovery of "the cellular origin of retroviral oncogenes". Press Release.
  2. ^ „Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)”. 
  3. ^ Ma, Juan; Zhang Guang-Yi (2003). „Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia”. Neurosci. Lett. Ireland. 348 (3): 185—9. ISSN 0304-3940. PMID 12932824. doi:10.1016/S0304-3940(03)00784-5. 
  4. ^ Takagi, N; et al. (1999). „The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains”. J. Cereb. Blood Flow Metab. UNITED STATES. 19 (8): 880—8. ISSN 0271-678X. PMID 10458595. doi:10.1097/00004647-199908000-00007. 
  5. ^ Cleghon, V; Morrison D K (1994). „Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner”. J. Biol. Chem. UNITED STATES. 269 (26): 17749—55. ISSN 0021-9258. PMID 7517401. 
  6. ^ Bourguignon, L Y; et al. (2001). „CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration”. J. Biol. Chem. United States. 276 (10): 7327—36. ISSN 0021-9258. PMID 11084024. doi:10.1074/jbc.M006498200. 
  7. ^ а б Beischlag, Timothy V; et al. (2002). „Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Mol. Cell. Biol. United States. 22 (12): 4319—33. ISSN 0270-7306. PMC 133867 Слободан приступ. PMID 12024042. doi:10.1128/MCB.22.12.4319-4333.2002. 
  8. ^ а б в Wan, Kah Fei; et al. (2003). „The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor”. J. Biol. Chem. United States. 278 (20): 18658—63. ISSN 0021-9258. PMID 12624098. doi:10.1074/jbc.M212103200. 
  9. ^ а б Olayioye, M A; et al. (1999). „ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases”. J. Biol. Chem. UNITED STATES. 274 (24): 17209—18. ISSN 0021-9258. PMID 10358079. doi:10.1074/jbc.274.24.17209. 
  10. ^ Cirri, P; et al. (1997). „c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells”. Biochem. Biophys. Res. Commun. UNITED STATES. 239 (2): 493—7. ISSN 0006-291X. PMID 9344858. doi:10.1006/bbrc.1997.7493. 
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  12. ^ Zisch, A H (2000). „Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses”. Oncogene. ENGLAND. 19 (2): 177—87. ISSN 0950-9232. PMID 10644995. doi:10.1038/sj.onc.1203304. 
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  28. ^ Zhou, Jian; et al. (2003). „Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer”. J. Biol. Chem. United States. 278 (9): 6936—41. ISSN 0021-9258. PMID 12473651. doi:10.1074/jbc.M210628200. 
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  32. ^ а б Kim, H J; et al. (1999). „Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation”. Mol. Cell. Biol. UNITED STATES. 19 (9): 6323—32. ISSN 0270-7306. PMC 84603 Слободан приступ. PMID 10454579. 
  33. ^ а б Slentz-Kesler, K; et al. (2000). „Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta”. Genomics. UNITED STATES. 69 (1): 63—71. ISSN 0888-7543. PMID 11013076. doi:10.1006/geno.2000.6299. 
  34. ^ Soutoglou, E; et al. (2000). „Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins”. J. Biol. Chem. UNITED STATES. 275 (17): 12515—20. ISSN 0021-9258. PMID 10777539. doi:10.1074/jbc.275.17.12515. 
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  38. ^ Shen, Z; et al. (1999). „Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src”. Oncogene. ENGLAND. 18 (33): 4647—53. ISSN 0950-9232. PMID 10467411. doi:10.1038/sj.onc.1203079. 
  39. ^ Finan, P M; et al. (1996). „Sam68 from an immortalised B-cell line associates with a subset of SH3 domains”. FEBS Lett. NETHERLANDS. 389 (2): 141—4. ISSN 0014-5793. PMID 8766817. doi:10.1016/0014-5793(96)00552-2. 
  40. ^ Brown, M T; et al. (1998). „ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src”. Mol. Cell. Biol. UNITED STATES. 18 (12): 7038—51. ISSN 0270-7306. PMC 109286 Слободан приступ. PMID 9819391. 
  41. ^ Li, Y; et al. (2001). „The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin”. J. Biol. Chem. United States. 276 (9): 6061—4. ISSN 0021-9258. PMID 11152665. doi:10.1074/jbc.C000754200. 
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  56. ^ He, Bin; Wilson Elizabeth M (2003). „Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Mol. Cell. Biol. United States. 23 (6): 2135—50. ISSN 0270-7306. PMC 149467 Слободан приступ. PMID 12612084. doi:10.1128/MCB.23.6.2135-2150.2003. 
  57. ^ Banin, S; et al. (1996). „Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases”. Curr. Biol. ENGLAND. 6 (8): 981—8. ISSN 0960-9822. PMID 8805332. doi:10.1016/S0960-9822(02)00642-5. 
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  59. ^ Moon, Sun Young; et al. (2003). „Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP”. J. Biol. Chem. United States. 278 (6): 4151—9. ISSN 0021-9258. PMID 12454018. doi:10.1074/jbc.M207789200. 
  60. ^ Brott, B K; et al. (1991). „Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein”. Mol. Cell. Biol. UNITED STATES. 11 (10): 5059—67. ISSN 0270-7306. PMC 361505 Слободан приступ. PMID 1717825. 
  61. ^ Giglione, C; et al. (2001). „Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm”. Eur. J. Biochem. Germany. 268 (11): 3275—83. ISSN 0014-2956. PMID 11389730. doi:10.1046/j.1432-1327.2001.02230.x. 
  62. ^ Gingrich, Jeffrey R; et al. (2004). „Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2”. Proc. Natl. Acad. Sci. U.S.A. United States. 101 (16): 6237—42. ISSN 0027-8424. PMC 395953 Слободан приступ. PMID 15069201. doi:10.1073/pnas.0401413101. 
  63. ^ Chang, B Y; et al. (1998). „RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells”. Mol. Cell. Biol. UNITED STATES. 18 (6): 3245—56. ISSN 0270-7306. PMC 108906 Слободан приступ. PMID 9584165. 

Literatura

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